Comparative Genome Analysis of an Extensively Drug-Resistant Isolate of Avian Sequence Type 167 Escherichia coli Strain Sanji with Novel In Silico Serotype O89b:H9 February 2019 mSystems 4(1) A retrospective genomic analysis of drug-resistant A retrospective genomic analysis of drug-resistant strains of M. tuberculosis in a high-burden setting, with an emphasis on comparative diagnostics and reactivation and reinfection status Kurt Wollenberg1*, Michael Harris1, Andrei Gabrielian1, Nelly Ciobanu2, Dumitru Chesov3,4, Alyssa Long1,
A retrospective genomic analysis of drug-resistant strains of M. tuberculosis in a high-burden setting, with an emphasis on comparative diagnostics and reactivation and reinfection status Kurt Wollenberg1*, Michael Harris1, Andrei Gabrielian1, Nelly Ciobanu2, Dumitru Chesov3,4, Alyssa Long1, Comparative Genomic Analysis of Mycobacterium Feb 20, 2013 · Abstract. Tuberculosis caused by multidrug-resistant (MDR) and extensively drug-resistant (XDR) Mycobacterium tuberculosis(MTB) strains is a growing problem in many countries. The availability of the complete nucleotide sequences of several MTB genomes allows to use the comparative genomics as a tool to study the relationships of strains and differences in their Comparative Genomic Analysis of Two Clonally Related Comparative genome analysis also suggested novel mutations at rv0888, lpdA, and cobM that might explain the difference in antibiotic resistance and growth pattern between the two MDR-TB strains. Keywords: Extensively Drug-Resistant Tuberculosis / drug therapy
Nov 01, 2020 · The several virulence and drug-resistance mechanisms of Pseudomonas aeruginosa responsible for poor clinical outcomes in keratitis patients remain largely unknown. Here, we investigated the distribution of virulence factors and drug resistance by genes, mutations, efflux-pump systems of P. aeruginosa strains from keratitis patients with different clinical outcomes, included of whole-genome Comparative proteomic analysis of Mycobacterium Dec 01, 2013 · While a genome remains unchanged to a larger extent, the proteins in any particular cell change dramatically as genes are turned on or off in response to the environment. Comparative genomic analysis of MTB H 37 Ra versus H 37 Rv by Zheng et al. revealed the genetic basis of virulence among these two strains . However, proteomics is still Evolution of Extensively Drug-Resistant Tuberculosis over Sep 29, 2015 · Conclusions. In the first whole genome-based analysis of the emergence of drug resistance among clinical isolates of M.tuberculosis, we show that the ancestral precursor of the LAM4 XDR outbreak strain in Tugela Ferry gained mutations to first-line drugs at the beginning of the antibiotic era.Subsequent accumulation of stepwise resistance mutations, occurring over decades and prior to
Nov 05, 2009 · Introduction. Outbreaks of extensively drug-resistant (XDR) tuberculosis have become an increasing threat in certain regions around the world .Though initially defined as resistance to isoniazid (INH), rifampicin (RIF), and 3 or more of the 6 classes of second-line drugs, the current definition of XDR-TB was changed by the WHO in 2006 to be:resistance to 1) INH, 2) RIF, 3) any of the Genome Sequence of Staphylococcus aureus Strain The absence of drug resistance genes reects the general antibiotic-susceptible phenotype of S. aureus and has been used extensively in animal models of were used for whole-genome comparative analysis with strain New-man. The genome sequences of strains Mu50 (BA000017) (18), NCTC8325 Genome-wide analysis of multi- and extensively drug To characterize the genetic determinants of resistance to antituberculosis drugs, we performed a genome-wide association study (GWAS) of 6,465 Mycobacterium tuberculosis clinical isolates from more than 30 countries. A GWAS approach within a mixed-regression framework was followed by a phylogenetics
Nov 01, 2018 · We isolated representative Korean A. baumannii strains from five Korean hospitals in five cities from 2015 to 2016 for comparative genomic analysis of Korean A. baumannii strains. All tested strains belonged to extensively drug-resistant (XDR) groups. Among them, A. baumannii KAB03 was selected because of its versatile resistance to clinically used antibiotics including colistin and its new Genomic characterization of extensively drug-resistant Nov 01, 2018 · We isolated representative Korean A. baumannii strains from five Korean hospitals in five cities from 2015 to 2016 for comparative genomic analysis of Korean A. baumannii strains. All tested strains belonged to extensively drug-resistant (XDR) groups. Among them, A. baumannii KAB03 was selected because of its versatile resistance to clinically used antibiotics including colistin and its new Whole genome sequencing uncovers a novel IND-16 Conclusions:In this study, we described the whole genome sequence of C. indologenes strain J31. Numerous resist-ance determinants were detected in the genome and might be responsible for the extensively antibiotic resistance of this strain. Comparative genomic analysis revealed the presence of considerable strain-specific genes which would
Genome analysis initially revealed two clones, one carrying bla OXA-23 on Tn 2006 (ST-1305, ST-195, and ST-218) and another carrying bla OXA-72 on pMAL-1 (ST-502 and ST-2059, a new ST), with the latter having two subclones, as revealed using the Bayesian transmission network. All isolates were extensively drug resistant (XDR). Whole-Transcriptome and -Genome Analysis of Extensively Nov 22, 2017 · Few studies have formally compared the transcriptomes of susceptible and resistant Mycobacterium tuberculosis strains. We carried out comparative whole-genome transcriptomics of extensively drug-resistant (XDR) clinical isolates using RNA sequencing (RNA-seq) to find novel transcription-mediated mechanisms of resistance. Frontiers Genome Sequences and Comparative Analysis of These genome sequences could serve as a useful reference for performing comparative genomics and evolutionary studies in the near future to increase the understanding of mechanisms of drug resistance in M. tuberculosis.